Prof. Dr. med. Klaus-Michael Debatin - Kinderonkologie, Ulm - Publikationen

Fulda, S, Wick, W, Weller, M, Debatin, K-M, 2002. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nature Medicine 8(8), 808-815.

Wei, J, Blum, S, Unger, M, Jarmy, G, Lamparter, M, Jarmy, G, Geishauser, A, Chan, G, Fischer, K-D, Rattat, D, Debatin, K-M, Hatzopoulos, AK, Beltinger, C, 2004. Embryonic endothelial progenitor cells armed with a suicide gene preferentially target hypovascular metastases. Cancer Cell 5(5), 477-488.

Mohr, A, Zwacka, RM, Jarmy, G, Büneker, C, Schrezenmeier, H, Döhner, K, Beltinger, C, Wisneth, M, Debatin, K-M, Stahnke, K, 2005. Caspase-8L expression contributes to the protecion of CD34+ hematopoietic progenitor cells from CD95-mediated apoptosis. Oncogene 24(14), 2421-2429.

Meyer, L-H, Karawajew, L, Schrappe, E, Ludwig, W-D, Stahnke, K, Debatin, K-M, 2006. Cytochrome c related caspase activation determines treatment response and relapse in childhood B-precursor ALL. Blood 107(11), 4524-3, 2006.

Fulda, S, Poremba, Ch, Berwanger, B, Häcker, S, Eilers, M, Christiansen, H, Hero, B, Debatin, K-M, 2006. Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease or prognosis in neuroblastoma. Cancer Research 66(20), 10016-23.

Corbacioglu, S, Kilic, M, Westhoff, MA, Reinhardt, D, Fulda, S, Debatin, KM, 2006. Newly identified c-kit receptor tyrosine kinase ITD in childhood AML induces ligand independent  growth and is responsive to a synergistic effect of imatinib and rapamycin. Blood 108(10), 3504-13.

Opel, D, Poremba, C, Simon, T, Debatin, K-M, Fulda, S, 2007. Activation of Akt predicts poor outcome in neuroblastoma. Cancer Research 67(2), 735-745.

Wei, J, Wahl, J, Nakamura, T, Stiller, D, Mertens, T, Debatin, KM, Beltinger, C, 2007. Targeted release of oncolytic measles viruses released from from blood outgrowth endothelial cells (BOECs) in situ inhibit orthotopic glioma. Gene Therapy 14, 1573-1586.

Debatin, K-M, 2007. Chronic Lymphocytic Leukemia: Keeping Cell Death at Bay. Cell 129(5), 853-855.

Meyer, LH, Queudeville, M, Eckhoff, SM, Creutzig, U, Reinhardt, D, Karawajew, L, Ludwig, W-D, Stahnke, K, Debatin, K-M, 2008. Intact apoptosis signaling in myeloid leukaemia cells determines treatment outcome in childhood AML. Blood 111(5), 2899-2903.

Vogler, M, Walczak, H, Stadel, D, Genze, F, Haas, T, Jovanovic, M, Gschwend, J, Simmet, T, Debatin, K-M, Fulda, S, 2008. Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo. Cancer Research 68(19), 7956-7965.

Gruhn, B, Taub, JW, Ge, Y, Beck, JF, Zell, R, Häfer, R, Hermann, FH, Debatin, KM, Steinbach, D, 2008. Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy. Leukemia 22(9), 1692-1697.

Fakler, M, Loeder, S, Vogler, M, Schneider, K, Jeremias, I, Debatin, KM, Fulda, S, 2009. Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood 113(8), 1710-1722

Strauss, G, Lindquist, JA, Arhel, N, Felder, E, Karl, S, Haas, T, Fulda, S, Walczak, H, Kirchhoff, F, Debatin, KM, 2009. CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling. Journal of Experimental Medicine 206: 1379-93.